Li Zhang - research works

A total of 2902 PDAC patients were seen by 1577 medical oncologists and underwent pancreatectomy from 736 different surgeons, representing 2295 unique surgeon-medical oncologist pairs.

The average age of diagnosis was 72 y (interquartile range: 68, 77), and approximately one-half were female (n = 1,447, 49.9%).

Two-thirds of patients (n = 1930, 67%) received care from a unique surgeon-medical oncologist pair (i.e., did not share any other patient).

Patients treated by the highest quartile of patient load volume of surgeons shared patients more frequently with medical oncologists than those treated by low-volume surgeons (n = 365, 38% versus n = 354, 19%; P < 0.001).

Multivariate analysis confirmed that the surgical method was not significantly associated with 3-year DFS [hazard ratio (HR), 0.767; 95% confidence interval (CI), 0.542-1.086; P = 0.135] or 3-year OS (HR, 0.774; 95% CI, 0.534-1.122; P = 0.177).

(2) Multivariate logistic regression analysis identified duration of symptoms, vomiting, and intussusception depth as independent risk factors for phloroglucinol treatment failure (all P < 0.05).

Calibration curves demonstrated excellent agreement between predicted probabilities and observed outcomes.

DCA indicated a significant clinical net benefit of the model.

The ASDR reached 1718 (1272, 2307) per 100,000, rising by 18.4% (5.3, 36.9) over the past three decades.

Depressive and anxiety disorders remained the dominant contributors, accounting for 35.6% and 26.3% of overall DALYs attributable to mental disorders, respectively.

Furthermore, eating disorders exhibited the largest growth in ASPR (63.4% [58.2, 68.2]).

Across the lifespan, the burden of DALYs was relatively higher in the 5-19, 30-39, and 50-59 age groups.

LASSO regression identified five predictors: hypertension, white blood cell count, lymphocyte percentage, basophil percentage, and monocyte count.

Several models showed comparable discrimination in the held-out internal test set.

SHAP analysis indicated that lymphocyte percentage, hypertension, monocyte count, white blood cell count, and basophil percentage were the major contributors to the predictions of the final model, with lymphocyte percentage showing the highest mean absolute SHAP value.

WGCNA revealed significant enrichment of the glycolysis/gluconeogenesis and pyruvate metabolism pathways, implicating metabolic reprogramming in FHP pathogenesis.

Differential analysis identified nine differentially expressed proteins, from which a six-protein signature (H2BC12, SHBG, APCS, PTPRG, IGHV1-58, and GAPDH) was derived through LASSO regression and recursive feature elimination.

This model represents a promising non-invasive molecular tool for the differential diagnosis of atypical interstitial lung diseases.

YF had higher complication rates (iridemia, cystoid macular edema, haptic exposure; P=0.039).

IOL tilt/decentration increased comparably in both groups.