Jie Yang - research works

Predictions were anchored after final operating-room schedule confirmation and primary surgical-team assignment but before incision, using 25 structured patient, disease, procedure, and surgical-team/scheduling predictors objectively available at that timestamp; intraoperative and postoperative variables were excluded.

The primary endpoint was a 30-day composite of clinically significant postoperative adverse events.

It outperformed ASA-only logistic regression (AUC 0.656) and a 21-predictor core-clinical logistic regression benchmark (AUC 0.895).

Proteomic analysis identified complement C3 as a highly specific rule-in biomarker for detecting post-burn BBB disruption.

Mechanistically, activation of the C3a/C3aR axis promoted mitochondrial dysfunction and maladaptive mitophagy in endothelial cells, leading to compromised BBB integrity, enhanced neuroinflammation, and cognitive impairment.

It is noted, however, that 177Lu with moderate radiation energy achieves effective tumor inhibition at a relatively high dose and has a low capacity to activate "cold" prostate tumor.

In this study, we report that Sigma-1 receptor and prostate-specific membrane antigen (PSMA) dual-targeted peptide (S1R/PSMA-P) labeled with 161Tb, which emits locally high linear energy transfer (LET) Auger electrons, effectively inhibits prostate tumor and energizes anticancer immunity.

Among 59 patients without immediate postoperative complete lower-limb paralysis, 46 (78.0%) recovered motor function immediately after surgery, and all recovered within 1 month.

Among 52 patients with immediate postoperative complete lower-limb paralysis, 18 (34.6%) recovered within 1 month, 47 (90.4%) recovered within 1 year, and 5 (9.6%) failed to return to baseline neurological status by final follow-up.

Crucially, 53.13% (17/32) occurred in endoscopically normal papillae, while 84.38% (27/32) of adenoma patients had prior negative endoscopic screenings.

Beyond Spigelman stage, significant correlations with papilla adenomas included combined gastric antral adenomas (R = 0.470, p = 0.037), use of transparent cap (R = 0.691, p = 0.003), and abnormal papillary appearance (R = 0.885, p < 0.001).

In this study, 89 patients (49.44%) were male and 91 (50.56%) were female.

The median age at surgery was 5.7 years.

66 patients (36.67%) were diagnosed with benign liver neoplasms (BLN), and 114 patients (63.33%) with malignant liver neoplasms (MLN).

The postoperative survival rate was 100% in both groups.

A risk model was created using multivariate logistic regression analysis.

Of the 522 patients, 174 (33.33%) experienced at least one major postoperative complication, including neurological, respiratory, renal, or other organ dysfunction.

Based on the logistic regression equation, logistic (P) = -7.458 + 0.056 × 1 + 0.102 × 2 + 0.374 × 3 + 0.018 × 4 + 0.026 × 5, a multivariate logistic regression risk model was developed to calculate the risk of postoperative complications, p = 1/1 + exp (-7.458 + 0.056 × 1 + 0.102 × 2 + 0.374 × 3 + 0.018 × 4 + 0.026 × 5).

Over the five-year study period, 7,764 students screened positive for suspected scoliosis, of whom 51.6% (n = 4,376) underwent further diagnostic evaluation.

The estimated prevalence of AIS over the five years was 1.08%.

Girls had higher positivity and PPV than boys and a greater proportion of severe cases.

The SSS program in Zhongshan identified students at risk and achieved a high diagnostic yield among those undergoing radiographic evaluation.

WGCNA revealed significant enrichment of the glycolysis/gluconeogenesis and pyruvate metabolism pathways, implicating metabolic reprogramming in FHP pathogenesis.

Differential analysis identified nine differentially expressed proteins, from which a six-protein signature (H2BC12, SHBG, APCS, PTPRG, IGHV1-58, and GAPDH) was derived through LASSO regression and recursive feature elimination.

This model represents a promising non-invasive molecular tool for the differential diagnosis of atypical interstitial lung diseases.