Huanwen Alvin Chen - research works

Of 22,387 patients (mean age 70.8 years; 29.6% female), 6,497 (29.0%) were readmitted within 90 days across diverse causes.

Non-SDH readmissions carried substantial clinical impact: infection readmissions had the highest mortality (9.6%), exceeding surgical SDH (2.9%) more than 3-fold, and the highest rate of new disability (45.5%) among patients initially discharged with routine self-care.

A total of 134 901 patients with conservatively managed nontraumatic SDH were identified, of whom 1470 (1.1%) were GLP-1 RA users.

After propensity score matching, 2922 patients remained, with 1461 in each group.

All-cause mortality was also significantly lower for GLP-1 RA users at 1 year (16.1% vs 23.7%, P < .001), reflecting a 33% reduction in hazards.

GLP-1 RA users did not experience different rates of adverse events, such as pancreatitis, gallbladder disease, or ileus/bowel obstruction (all P > .05).

MMA-OA/LA anastomoses were seen on MRA for 6 (46%) patients, all confirmed on DSA.

Among patients with no MRA evidence of anastomoses, none were found to have anastomoses on DSA.

MMA-OA anastomoses were used as the primary delivery route of IAC for 3 patients (50% of patients with a confirmed presence of MMA-OA anastomoses).

Overall procedural success was 98% (41/42).

Among 710 enrolled patients across 36 centers, 688 comprised the final analysis cohort.

Median puncture-to-clot contact and puncture-to-reperfusion times were 13 and 17 min, respectively.

Symptomatic intracranial hemorrhage occurred in 0.6% of patients, and the all-cause mortality rate at 90 days was 16.3%.

Embolization to new territory occurred in 0.4%, and 52.9% of patients achieved functional independence (modified Rankin Scale ≤2) at 90 days.