Haitao Zhang - research works

There were no significant differences in baseline characteristics (age, gender, BMI, surgical parameters, scoliosis type, preoperative/postoperative Cobb angles) between the two groups (all p > 0.05).

Preoperatively, SRS-22 and SF-36 scores showed no inter-group differences (all p > 0.05).

Both groups showed significant improvements in physical function-related dimensions postoperatively.

The Non-Negative Emotion Group also exhibited significant improvements in SRS-22 self-image/pain and SF-36 bodily pain (all p < 0.05), while the Negative Emotion Group showed no significant improvements in these dimensions.

These findings are descriptive; temporal trends and exposure-outcome associations were not assessed in the present cohort profile.

FUTURE PLANS: The GDPU-OHC will continue prospective follow-up to capture long-term NCD outcomes and repeated occupational health information.

A total of 161 patients (32.2%) developed AKI.

Among them, 46 classified as moderate to severe AKI.

Compared with patients without AKI, patients with AKI had a significantly higher RPI at T3 (1.30 ± 0.28 vs 1.44 ± 0.34, P = 0.004), while no significant differences were observed at the other time points.

The restricted cubic splines revealed an RPI cutoff value of 1.305 at T3, above which the risk of AKI increased proportionally.

Among the 28 patients, 18 underwent surgical Potts shunt creation (100% requiring cardiopulmonary bypass [CPB], median CPB duration: 91[82-108] minutes) and 10 underwent transcatheter procedures (20% requiring CPB).

Anesthesia induction predominantly utilized ciprofol-alfentanil (60.7%) and s-ketamine (28.6%).

Preoperative treprostinil was universal, with 7.1% of patients requiring additional vasoactive agents.

Post-shunt hemodynamic support included norepinephrine (92.9%), dopamine (28.6%) and dobutamine (28.6%).

Results showed that higher levels of these indices were significantly associated with increased neovascularization severity.

The pan-immune-inflammation value showed a high sensitivity of 88.6% for initial screening while the Systemic Inflammation Response Index demonstrated 78.3% specificity for confirming plaque instability.

Adding SII to the baseline model improved reclassification and discrimination after bootstrap correction, with a continuous NRI of 0.949 (95% CI: 0.752-1.153) and an IDI of 0.266 (95% CI: 0.213-0.311).

Baseline demographic, anatomical, and endocrine characteristics were comparable between groups.

At 6 months, headache/ICP-related symptoms improved in 90.9% of EEA patients versus 76.5% of TCA patients (p=0.047).

0.42 [0.22, 0.62], p=0.041).

To address this challenge, a histopathomics-based survival prediction system (HPSurv) was developed using histopathological whole-slide images (WSIs) for individualized overall survival (OS) prediction.

Within this framework, pathological tissue classification, quantitative characterization of tumor spatial heterogeneity, and a survival Transformer were integrated to enable multi-level representation learning from histopathological data.

The system was developed and evaluated in 1020 patients across five independent cohorts.

Existing algorithms provide coarse risk stratification or static binary predictions, failing to capture the time-varying risk of death.

We developed and externally validated TEMPO-HCC, a multimodal deep survival model with hierarchical interpretability, to estimate individualized overall survival risk trajectories after curative-intent resection.

A discrete-time survival head generated probabilities at 1, 2, 3, and 5 years after surgery.

TEMPO-HCC represents a paradigm shift from static binary classification toward clinically actionable temporal risk prediction.

Papillary thyroid cancer was the most common NTRK-positive tumor (49.74%) and harbored all 3 NTRK subtypes.

Among NTRK-positive samples, NTRK3 (74.87%) was the most prevalent subtype, followed by NTRK1 (23.59%).

ETS variant transcription factor 6 (ETV6) was the most frequent fusion partner identified in 122 of 195 cases.

Particularly, the detection sensitivity for NTRK3 fusions was significantly enhanced and reached 95.89%.

In total, 151 proteins were significantly altered in the retina of diabetic mice.

Among these 151 candidates, 22 genes presented a significant correlation with blood glucose level (p<0.05), which were enriched in alanine, aspartate, and glutamate metabolism (p=0.003).

Moreover, the glutamate catabolism-related genes Slc1a2, Gad1, and Glud1 were significantly negatively correlated with blood glucose at the transcript and proteome levels, which led to glutamate accumulation under hyperglycemia.

Moreover, Grm6 expression was significantly decreased at both the mRNA and protein levels in the diabetic retina.