Emeline Chaugne - research works

Eye pain was reported in 58.1% of cases, phosphenes in 14%, and visual symptoms were bilateral in 39.5%.

Orbital MRI patterns differed by aetiology: unilateral hemichiasmal T2-weighted involvement was significantly more frequent in MS than in non-MS patients (74.1% vs 25%, p = 0.004).

Median time to intravenous methylprednisolone was 19 days (IQR 9.8-32.3).

At one year, normal visual acuity was recovered in 55.4% of patients.

Longitudinally extensive lesions, bilateral involvement, chiasmal enhancement, or optic perineuritis were observed in 100% of non-MS patients and 24.6% of patients with MS (difference 75.4%, 95% CI: 64.3-86.6; p < 0.001).

All patients without these patterns were ultimately diagnosed with MS.

Overall, 433 patients (median age, 69.3 years, 228 females [52.8%]) were assigned to an individualized BP group (n = 215) or the control BP group (n = 218); one was excluded because of consent withdrawal.

No significant differences in mean BP levels or BP variability were observed between groups during the procedure.

Mortality from any cause at 90 days was not significantly different between groups (18.8% in the individualized BP group vs 16.4% in the control BP group: adjusted odds ratio, 1.19; 95% CI 0.70-2.03).

Rates of symptomatic intracranial hemorrhages were not different between the 2 groups.