Andrew Mihalache - research works

Meta-regression revealed that lower OSSN prevalence was associated with greater distance from the equator (OR 0.49, 95% CI 0.28 to 0.83, p<0.01), while higher prevalence was associated with greater UV exposure (OR 2.20, 95% CI 1.17 to 4.14, p=0.01).

Publication year had no effect (p=0.98).

Incidental OSSN prevalence also did not differ between primary and recurrent pterygia (p=0.23).

Regional analyses revealed variation in prevalence: Europe (0.29%), Asia (0.76%), North America (1.03%), Oceania (8.57%) and South America (14.97%).

There were a total of 4,084 reports of AEs associated with tamoxifen (mean age 56.7 years), including 505 ocular AEs.

The strongest signals were for corneal graft rejection (ROR 118.9), retrobulbar hemorrhage (104.6), ophthalmic vein thrombosis (82.7), retinal deposits (80.7), and macular hole (78.6).

Additional events included maculopathy, retinopathy, and optic neuropathy.

There were 5,600 reports of AEs associated with raloxifene (mean age 68.6 years), including 437 ocular AEs.

For next-step decisions, DeepSeek-R1 was correct in 82.7% of cases (349 of 422 cases) vs OpenAI o1's accuracy of 75.8% (320 of 422 cases), a 6.9% difference (95% CI, 1.4%-12.3%; P = .01).

Intermodel agreement was moderate (κ = 0.422; 95% CI, 0.375-0.469; P < .001).

DeepSeek-R1 offered lower costs per query than OpenAI o1, with savings exceeding 66-fold (up to 98.5%) during off-peak pricing.