Validating pancreatic stone protein for early sepsis detection and outcome prediction in community acquired infections: evidence from a tertiary medical centre.

Pancreatic stone protein is a valuable biomarker that can rule out patients who do not have sepsis and are not in high risk to develop sepsis the following days, giving valuable insights regarding their antimicrobial coverage and management in general.

It seems to be superior to other biomarkers in sepsis prediction and adequately compatible with frequently used sepsis assessment scores, such as Sequential Organ Failure Assessment.

In the Emergency Department setting pancreatic stone protein can distinguish infected patients at high risk for sepsis who have low qSOFA scores.