Motor mapping to enable resections of peri-rolandic diffuse gliomas.

Cohort studyJournal of neuro-oncology· Jul 2026

Motor mapping to enable resections of peri-rolandic diffuse gliomas.

James S Trippett, Antonio Dono, Syed S Shams … Nitin Tandon

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Neurosurgical OncologyCohort studyQ2IF 3.2

Awake and asleep motor mapping show similar neurological deficit rates in glioma surgery.

Motor mapping to enable resections of peri-rolandic diffuse gliomas.

James S Trippett … Nitin Tandon

Journal of neuro-oncology · Jul 2026 · Q2 in Neurology

Background

Intraoperative motor mapping is essential for maximum safe resection of peri-Rolandic gliomas.

Methods

Were stratified by mapping modality (awake n = 54, asleep n = 76) and tumor subtype (WHO 2021).

n = 54,

Results

similar deficit rates, awake mapping showed no safety advantage over asleep mapping

5.6%

Awake

5.3%

Asleep

More results

In glioblastoma patients, pre- and postoperative Karnofsky Performance Status were significantly lower in the asleep group (p < 0.001 and p = 0.002), though delta Karnofsky Performance Status and 3-month deficit rates did not differ.

No deficits occurred in either group among IDH-mutant gliomas.

More results

Progression-free and overall survival were comparable between mapping modalities in glioblastoma.

“

Conclusion · 1 of 2

Awake and asleep motor mapping were associated with comparable neurological outcomes across glioma subtypes, supporting asleep mapping as a reasonable alternative when awake craniotomy is not feasible, though these retrospective data do not establish statistical equivalence.

Conclusion · 2 of 2

HHP-DCS and SDE-DCS appear comparable in safety. Larger prospective studies are needed to confirm these findings.

Motor mapping to enable resections of peri-rolandic diffuse gliomas.

Motor mapping to enable resections of peri-rolandic diffuse gliomas.

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