Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic…

Randomized trialTherapeutic advances in neurological disorders· 2026

Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion: A secondary analysis of the MARVEL trial.

Lijiao Zhang, Jie Pan, Lilan Wang … Gaoming Li

NeuroendovascularRandomized trialQ1IF 3.6

Methylprednisolone linked to better stroke outcomes than placebo in men, not women

Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion: A secondary analysis of the MARVEL trial.

Lijiao Zhang … Gaoming Li

Therapeutic advances in neurological disorders · 2026 · Q1 in Neurology

Background

Sex-based differences in treatment response to neuroprotective strategies during endovascular treatment (endovascular treatment) for acute ischemic stroke remain poorly understood.

Purpose

This study aimed to evaluate sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion.

Methods

Secondary analysis of the MARVEL (Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke) randomized controlled trial.

n = 1680 patients

Results

men had higher odds of a better 90-day disability outcome with methylprednisolone

OR 1.26 (95% CI 1 to 1.59)

CI crosses the null - not significant

More results

This study included 1680 patients (49.9% methylprednisolone, 56.7% men).

Additionally, stratified by different treatment arms, no significant difference was found in the primary outcome between men and women treated with methylprednisolone ( P = 0.31) and placebo ( P = 0.68).

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Conclusion · 1 of 2

In this exploratory analysis, methylprednisolone appeared to be associated with better clinical outcomes in men compared with placebo. Nevertheless, the interaction between treatment and sex was not statistically significant.

Conclusion · 2 of 2

Furthermore, among patients receiving methylprednisolone, clinical outcomes did not differ significantly between men and women.

Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion: A secondary analysis of the MARVEL trial.

Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion: A secondary analysis of the MARVEL trial.

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