Early Predictive Value of Peripheral Inflammatory Index Combined with High-Sensitivity Troponin T for…

Cohort studyMediterranean journal of hematology and infectious diseases· 2026

Early Predictive Value of Peripheral Inflammatory Index Combined with High-Sensitivity Troponin T for Sepsis-Induced Cardiomyopathy.

ChunYan Zong, FeiFeng Wu, Xin Chu … BaoFeng Zhu

Acute Chest Pain & TroponinCohort studyQ3IF 1.6

Adding NLR to troponin T improved sepsis-induced cardiomyopathy prediction, AUC 0.860

Early Predictive Value of Peripheral Inflammatory Index Combined with High-Sensitivity Troponin T for Sepsis-Induced Cardiomyopathy.

ChunYan Zong … BaoFeng Zhu

Mediterranean journal of hematology and infectious diseases · 2026

Background

Sepsis-induced cardiomyopathy (sepsis-induced cardiomyopathy) is a common and serious complication of sepsis, and early identification remains challenging.

Methods

A total of 319 adult patients with a first diagnosis of sepsis between June 2022 and January 2025 were enrolled.

n = 319 adult

Results

adding NLR to troponin improved prediction accuracy, near-perfect on a 0-1 scale

hs-cTnT baseline

0.825AUC

+SII

0.856AUC

+NLR

0.86AUC

More results

Among 319 patients with sepsis, 115 (36.1%) developed sepsis-induced cardiomyopathy.

Compared with the non-sepsis-induced cardiomyopathy group, patients with sepsis-induced cardiomyopathy had significantly higher hs-cTnT levels, indicating more severe myocardial injury.

More results

Peripheral inflammatory indices were also higher overall, with the largest between-group differences observed for SII and NLR.

SIRI and PLR were also elevated, whereas PIV showed a smaller difference (all P<0.05).

“

Conclusion · 1 of 2

SII and NLR, as readily available peripheral inflammatory markers, were associated with improved early prediction of sepsis-induced cardiomyopathy when combined with hs-cTnT.

Conclusion · 2 of 2

This combined strategy may help refine early risk stratification in patients with sepsis.