Association of Prostate Multiparametric MRI Parameters with Gleason Score: A Fusion Biopsy-Based Correlation.
Apparent diffusion Coefficient cutoff of 0.70 predicted high-grade prostate cancer with 92% sensitivity, specificity
Association of Prostate Multiparametric MRI Parameters with Gleason Score: A Fusion Biopsy-Based Correlation.
This study aimed to investigate the relationship between imaging parameters obtained from Multiparametric Magnetic Resonance İmaging (MPMRI) and Gleason Scores (Gleason Scores) derived from targeted prostate biopsies performed using MRI/Ultrasound (ultrasound) fusion guidance.
A total of 120 consecutive patients who underwent 1.5T MP-MRI followed by MRI/ultrasound fusion-guided prostate biopsy were included.
Apparent diffusion Coefficient below this threshold flags high-grade cancer with high sensitivity and specificity
Of the 202 targets, 138 (68.3%) were benign, 35 (17.3%) had Gleason Scores 3+4 (low-grade), and 29 (14.4%) had Gleason Scores ≥4+3 (high-grade) malignancy.
Apparent diffusion Coefficient values were negatively correlated with age, Prostate-Specific Antigen, Prostate Density, and PI-RADS score.
Most lesions were located in the peripheral zone, particularly in the mid-gland and apical regions.
Malignant lesions were frequently found in the peripheral zone and right mid-gland.
Correlation of MP-MRI-derived imaging parameters with histopathology results allows meaningful exploitation in clinical decision-making in prostate cancer diagnosis.
Both the PI-RADS score and the apparent diffusion Coefficient value were validated as reliable predictors of tumor aggressiveness.
Although MRI-targeted fusion biopsies have gained more and more popularity in clinical practice, based on our data, no conclusion can be drawn as to their effect in decreasing the number of unnecessary prostate biopsies.