Independent risk factors for clinically significant acute poisoning in children presenting to the emergency department: a 4-year cohort study of 2,345 cases.

Readily identifiable risk factors-age >12 years, self-harm, delay >6 h, multiple-agent exposure, and exposure to herbicides or psychotropics-independently predict clinically significant pediatric poisoning.

The PSS ≥ 2 classification correlates tightly with acute organ dysfunction and Multiple Organ Dysfunction Syndrome (Multiple Organ Dysfunction Syndrome).