Diagnostic value of EUS-guided tissue acquisition in suspected autoimmune pancreatitis: A 15-year…

Cohort studyEndoscopic ultrasound· 2026

Diagnostic value of EUS-guided tissue acquisition in suspected autoimmune pancreatitis: A 15-year single-center retrospective study.

Wei Du, Yuyan Zhou, Haojie Huang … Zhendong Jin

CytopathologyCohort studyDiagnosisQ1IF 3.4

EUS-guided fine-needle biopsy outperformed fine-needle aspiration for diagnosing autoimmune pancreatitis.

Diagnostic value of EUS-guided tissue acquisition in suspected autoimmune pancreatitis: A 15-year single-center retrospective study.

Wei Du … Zhendong Jin

Endoscopic ultrasound · 2026

Background

Autoimmune pancreatitis is a distinct type of pancreatitis mediated by autoimmune processes.

Purpose

The objective of this study is to assess the diagnostic value of EUS-guided tissue acquisition (including EUS-FNA and EUS-FNB) in patients with suspected AIP.

Methods

Suspected of AIP who underwent EUS-guided tissue acquisition (EUS-TA) at Changhai Hospital between 2010 and 2025.

n = 148 patients

90.48%

Results

90.48%

vs. 78.13%

biopsy was far more accurate than aspiration for confirming autoimmune pancreatitis

n = 148 patients

More results

Ultimately, 131 were diagnosed with AIP, 9 with pancreatic malignancy, and 8 with other pancreatic diseases.

Among the 131 patients diagnosed with AIP, EUS-TA achieved a success rate of 88.66% for obtaining histopathological evidence in type 1 AIP, 76.47% in type 2 AIP, and 85.5% overall for AIP.

More results

The ROC curve indicates that EUS-TA demonstrates good diagnostic value for patients suspected of having AIP (AUC = 0.839, 95% CI: 0.729-0.95).

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Conclusion

EUS-guided tissue acquisition demonstrates good diagnostic value for patients suspected of AIP, with EUS-FNB showing higher diagnostic value for AIP than EUS-FNA. EUS-FNB is the preferred diagnostic method for patients suspected of AIP.