MicroRNA and Inflammatory Biomarker Signatures Associated With Neurological Outcome After Out-Of-Hospital…

Cohort studyEuropean journal of clinical investigation· Aug 2026

MicroRNA and Inflammatory Biomarker Signatures Associated With Neurological Outcome After Out-Of-Hospital Cardiac Arrest: The MiRacle Study.

Francisco Rafael Jiménez-Trinidad, Eva Moreno-Monterde, Carlos Roca-Guerrero … Rut Andrea

Resuscitation & Cardiac ArrestCohort studyQ1IF 4.0

miR-499a-5p at 24 hours predicted poor neurological outcome after cardiac arrest

MicroRNA and Inflammatory Biomarker Signatures Associated With Neurological Outcome After Out-Of-Hospital Cardiac Arrest: The MiRacle Study.

Francisco Rafael Jiménez-Trinidad … Rut Andrea

European journal of clinical investigation · Aug 2026 · Q1 in General Medicine

Background

Early neuroprognostication in Out-of-Hospital Cardiac Arrest (Out-of-Hospital Cardiac Arrest) remains challenging due to the lack of reliable biomarkers.

Purpose

This study aimed to evaluate whether in silico-predicted microRNAs could discriminate neurological outcomes early in Out-of-Hospital Cardiac Arrest patients.

Methods

Consecutive Out-of-Hospital Cardiac Arrest patients admitted to the Acute Cardiac Care Unit with available cryopreserved blood samples were analysed.

n = 100 patients

Results

AUC 0.645

higher levels only weakly separated poor from good neurological outcome

n = 100 patients

More results

53% had unfavourable neurological outcomes.

Eleven candidate microRNAs were identified, showing differential time-dependent expression within 72 h.

The miR-499-5p maintained the best AUC across all time-points.

A multiparametric model achieved an AUC of 0.690.

“

Conclusion

In silico derived inflammatory and HIBI-related microRNAs showed time-dependent expression patterns that may distinguish neurological outcomes within 72 h after Out-of-Hospital Cardiac Arrest.

MicroRNA and Inflammatory Biomarker Signatures Associated With Neurological Outcome After Out-Of-Hospital Cardiac Arrest: The MiRacle Study.

MicroRNA and Inflammatory Biomarker Signatures Associated With Neurological Outcome After Out-Of-Hospital Cardiac Arrest: The MiRacle Study.

Related papers