Propylene carbonate-PVDF-HFP/MXene-based self-powered biosensor for auxiliary detection of salivary exosomal…

StudyBiosensors & bioelectronics· Nov 2026

Propylene carbonate-PVDF-HFP/MXene-based self-powered biosensor for auxiliary detection of salivary exosomal miRNA-155 in pediatric asthma.

Tiantian Sun, Fangyan Ji, Zhenrun Li, Qiang Ma

Pediatric RespiratoryStudyQ1IF 11.5

Self-powered biosensor detects salivary exosomal miRNA-155 for pediatric asthma with high sensitivity

Propylene carbonate-PVDF-HFP/MXene-based self-powered biosensor for auxiliary detection of salivary exosomal miRNA-155 in pediatric asthma.

Tiantian Sun … Qiang Ma

Biosensors & bioelectronics · Nov 2026 · Q1 in General Medicine

Purpose

This study developed a novel integrated self-powered biosensor for non-invasive auxiliary detection of pediatric asthma-associated miRNA-155.

Results

0.21

fM

Detection limit of 0.21 fM shows the biosensor picks up even very low miRNA-155 levels.

More results

Meanwhile, the cathode was designed based on [Ru(NH 3 ) 6 ] 3+ as efficient electron acceptors.

As a result, the glucose oxidation reaction at the anode and the reduction of [Ru(NH 3 ) 6 ] 3+ at the cathode generated a measurable open-circuit voltage (E OCV ), which was real-time recorded through smartphone integration.

More results

The development of self-powered biosensor overcame the limitations of the low power output, functional layer detachment, and active site deactivation.

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Conclusion

This work constructed a robust and portable platform suitable for non-invasive auxiliary detection of pediatric asthma, demonstrating promising applications in liquid biopsy.