MRI-DERIVED POPLITEAL ARTERY WALL BIOMARKERS AND HIP OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE.
Higher popliteal artery wall index linked to greater odds of hip osteoarthritis
MRI-DERIVED POPLITEAL ARTERY WALL BIOMARKERS AND HIP OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE.
Vascular health has been implicated in OA pathogenesis, but evidence specific to hip OA remains limited.
To evaluate whether baseline knee MRI-derived popliteal artery wall measurements are associated with prevalent and 4-year incident radiographic hip OA (rHOA), symptomatic hip OA (sHOA), and frequent hip pain in the Osteoarthritis Initiative.
This observational study included OAI participants with available baseline knee MRI and hip radiographs.
higher popliteal artery wall thickening raised odds of hip osteoarthritis
At baseline, 521/8,506 hips (6.1%) had rHOA and 264/8,506 hips (3.0%) had sHOA.
Mean age and BMI were 60.7 ± 9.1 years and 28.2 ± 4.7 kg/m², respectively.
Over 4 years, 96/6,224 hips (1.5%) developed incident rHOA, 46/6,224 hips (0.7%) developed incident sHOA, and 809/6,302 hips (12.8%) developed incident frequent hip pain.
Baseline popliteal artery wall measurements were not associated with incident rHOA or sHOA; however, higher mean normalized wall index was associated with incident frequent hip pain (OR 1.16, 95% CI 1.05-1.27; p=0.002).
Automated knee MRI-derived popliteal artery wall biomarkers were associated with prevalent rHOA, sHOA, and frequent hip pain, and mean normalized wall index was associated with 4-year incident frequent hip pain.
These findings support opportunistic vascular assessment on knee MRI as a potential imaging marker of vascular-metabolic hip OA and pain phenotypes, although short-term associations with incident structural hip OA were not observed.