Plasma metabolomic signatures of heterogeneous multimorbidity trajectories in ageing: a population-based cohort study.

Monthly cumulative Charlson Comorbidity Index scores were constructed from aligned cohort entry to 60 months to capture accumulation of newly documented Charlson conditions after follow-up start.

Six trajectories ranged from minimal accumulation to rapid progression.

Nineteen metabolites were associated with greater trajectory severity after false discovery rate correction.

Eighteen of these metabolites were also associated with time to first newly documented Charlson disease.