Multimodality imaging characterization of Perugini scintigraphic grades in transthyretin amyloid cardiomyopathy: a single-center experience.

Among 302 scans, 103 (34.1%) had reported cardiac uptake on planar imaging.

Fifty-three patients were diagnosed with ATTR-CM, including 8 (15.1%) with grade 2 and 45 (84.9%) with grade 3 uptake.

Grade 3 patients exhibited worse functional status, shorter 6-min walk distance, and higher troponin I levels.

In the subset with cardiac magnetic resonance (n = 38), grade 3 patients (n = 30) had significantly higher left ventricular mass index, extracellular volume fraction, right ventricular free wall thickness, and more frequent right ventricular involvement.