Estimation of effective half-life and lesion-specific kinetics in I-131 therapy for differentiated thyroid cancer using dual-timepoint imaging.

Dual-timepoint planar imaging incorporating internal capsule calibration enables reproducible estimation of lesion-specific T eff in patients undergoing I-131 therapy for differentiated thyroid cancer.

This approach achieves a practical balance between quantitative accuracy and clinical feasibility, enabling reliable characterization of iodine kinetics with minimal imaging burden and supporting individualized dosimetry in routine clinical practice.