Personalized lung dosimetry evaluated by 90 Y PET/CT in radioembolization: dosimetric correlations and…

Cohort studyJapanese journal of radiology· Jul 2026

Personalized lung dosimetry evaluated by 90 Y PET/CT in radioembolization: dosimetric correlations and exploratory observations on radiation pneumonitis.

Yi-Chieh Chen, Po-Chin Liang, Chih-Horng Wu … Mei-Fang Cheng

TheranosticsCohort studyTreatmentQ1IF 4.9

Personalized lung mass estimates correlate more closely with actual post-treatment radiation dose than standard model

Personalized lung dosimetry evaluated by 90 Y PET/CT in radioembolization: dosimetric correlations and exploratory observations on radiation pneumonitis.

Yi-Chieh Chen … Mei-Fang Cheng

Japanese journal of radiology · Jul 2026 · Q1 in Radiology

Purpose

To evaluate whether personalized lung mass improves pre-treatment lung dose estimation accuracy compared to the 1000-g lung model, using post-treatment 90 Y PET/CT as the reference.

Methods

A retrospective analysis was conducted on 100 patients treated with 90 Y radioembolization from 2018 to 2025.

n = 100 patients

Results

personalized dosing tracked more closely with each patient's actual treatment dose

Personalized lung dose

0.678r

1000-g model

0.612r

More results

The mean lung mass (760.11 ± 144.89 g) was significantly lower than the 1000-g model (P < 0.001).

Two patients (2%) developed radiation pneumonitis, and both had baseline lung metastases (28% overall).

4.3% [range, 1.0-14.5%]).

“

Conclusion · 1 of 2

Personalized dosimetry improves predictive accuracy and mitigates sex-related dosimetric bias, suggesting CT-derived lung mass should be considered to optimize 90 Y radioembolization precision.

Conclusion · 2 of 2

Given our limited sample size, the association between pre-existing lung metastases and radiation pneumonitis warrants further investigation.

Personalized lung dosimetry evaluated by 90 Y PET/CT in radioembolization: dosimetric correlations and exploratory observations on radiation pneumonitis.

Personalized lung dosimetry evaluated by 90 Y PET/CT in radioembolization: dosimetric correlations and exploratory observations on radiation pneumonitis.

Related papers