The causal impact of gut microbiota on allergic rhinitis mediated by cerebrospinal fluid metabolites: A study based on Mendelian randomization and mediation analysis.
Gut microbe Peptococcia abundance is associated with higher allergic rhinitis risk
The causal impact of gut microbiota on allergic rhinitis mediated by cerebrospinal fluid metabolites: A study based on Mendelian randomization and mediation analysis.
In recent years, the role of gut microbiota (gut microbiota) in the pathogenesis of allergic diseases (allergic diseases) has garnered increasing attention, yet the influence of the brain and its metabolites (such as cerebrospinal fluid [CSF] metabolites) remains unclear.
This study aims to investigate whether gut microbiota mediates its effect on allergic rhinitis (allergic rhinitis) through CSF metabolites and to quantify this mediating effect, while systematically evaluating the causal relationships between brain functional networks/CSF metabolites and multiple allergic diseases to elucidate the potential roles of brain-related factors in allergic mechanisms.
Specifically, we performed: mediation mendelian randomization to test the GM-CSF metabolites-allergic rhinitis pathway; and 2-sample mendelian randomization to assess causal relationships between brain functional networks/CSF metabolites and allergic diseases.
higher Peptococcia levels raise the odds of allergic rhinitis
Using large-scale genome-wide association study data, including gut microbiota (n = 7738), brain functional networks (n = 47,276), CSF metabolites (n = 291), and 7 categories of allergic diseases (Finnish R12 database), we applied Mendelian randomization (mendelian randomization) for causal inference.
Genetically predicted analyses revealed significant associations between gut microbiota and both CSF metabolites and allergic rhinitis.
These findings deepen understanding of the "gut-brain-immune" axis mechanism and provide new directions for future precise interventions targeting metabolites and neuroimmune pathways.