Efficacy and safety of the JAK1 inhibitor abrocitinib for moderate-to-severe atopic dermatitis: a systematic…

Systematic reviewFrontiers in pharmacology· 2026

Efficacy and safety of the JAK1 inhibitor abrocitinib for moderate-to-severe atopic dermatitis: a systematic review and meta-analysis.

Bobiao Ning, Baohua Li, Quan Luo, Ping Song

Allergy & ImmunologySystematic reviewTreatmentQ1IF 5.1

Abrocitinib nearly triples Investigator's Global Assessment response in moderate-to-severe atopic dermatitis

Efficacy and safety of the JAK1 inhibitor abrocitinib for moderate-to-severe atopic dermatitis: a systematic review and meta-analysis.

Bobiao Ning … Ping Song

Frontiers in pharmacology · 2026

Background

Atopic dermatitis (atopic dermatitis) is a chronic inflammatory disease with substantial pruritic burden.

Methods

Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance, PubMed, Embase, Web of Science, and the Cochrane Library were searched to 21 August 2025 for randomized controlled trials (randomized controlled trials) comparing abrocitinib with placebo.

n = 1,927 patients

Results

IGA clear or almost-clear skin nearly triples with abrocitinib versus placebo

RR by subgroup · 95% CI

More results

Treatment-emergent adverse events were increased (RR = 1.18, 95% CI: 1.10-1.27), mainly nausea (RR = 5.53, 95% CI: 3.41-9.34).

Headache was also increased overall (RR = 1.64, 95% CI: 1.16-2.47), whereas skin allergy was reduced (RR = 0.58, 95% CI: 0.44-0.82).

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Conclusion · 1 of 2

Abrocitinib provides clinically meaningful short-term improvements in disease severity and pruritus in moderate-to-severe atopic dermatitis.

Conclusion · 2 of 2

The 200 mg dose offers greater efficacy but requires careful monitoring for tolerability, particularly nausea and headache.

Efficacy and safety of the JAK1 inhibitor abrocitinib for moderate-to-severe atopic dermatitis: a systematic review and meta-analysis.

Efficacy and safety of the JAK1 inhibitor abrocitinib for moderate-to-severe atopic dermatitis: a systematic review and meta-analysis.

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