Seasonal variation and risk of paclitaxel-induced hypersensitivity reactions: A retrospective cohort study.

Cohort studyJournal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners· Aug 2026

Seasonal variation and risk of paclitaxel-induced hypersensitivity reactions: A retrospective cohort study.

Jessica Bylyku, Katherine Vicinanza-Rickard, John Timoney … Autumn Guyer

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Allergy & ImmunologyCohort studyQ3IF 1.4

Fall months linked to higher odds of paclitaxel hypersensitivity reactions in adjusted analysis

Seasonal variation and risk of paclitaxel-induced hypersensitivity reactions: A retrospective cohort study.

Jessica Bylyku … Autumn Guyer

Journal of oncology pharmacy practice · Aug 2026 · Q3 in General Medicine

Background

Many anticancer agents are associated with immediate hypersensitivity reactions, and taxanes are among the most frequently implicated drug class.

Methods

This was a retrospective, single-center, Institutional Review Board-approved review of adult patients who received at least one paclitaxel infusion at our institution between November 20, 2023, and December 31, 2024.

n = 2526 patients

Results

hypersensitivity odds rose in fall months versus other seasons

OR 1.52 (95% CI 1.14 to 2.02)

CI excludes the null - significant

More results

Of 2526 patients included, 554 (22%) experienced a hypersensitivity reaction to paclitaxel.

The largest proportion of hypersensitivity reactions occurred during the winter months, with 29% of all hypersensitivity reactions occurring during December, January, and February.

“

Conclusion

Seasonal variation was associated with paclitaxel-induced hypersensitivity reactions, with fall months demonstrating increased risk in adjusted analyses. These findings are exploratory and warrant validation in larger, multicenter datasets.

Seasonal variation and risk of paclitaxel-induced hypersensitivity reactions: A retrospective cohort study.

Seasonal variation and risk of paclitaxel-induced hypersensitivity reactions: A retrospective cohort study.

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