The Utility of Sex-Specific Cut-offs for High-Sensitivity Troponin T for Long-Term All-cause Mortality Risk…

Cohort studyRomanian journal of internal medicine = Revue roumaine de medecine interne· Jun 2026

The Utility of Sex-Specific Cut-offs for High-Sensitivity Troponin T for Long-Term All-cause Mortality Risk Assessment in Heart Failure.

Anamaria Draghici, Caterina Delcea, Gheorghe-Andrei Dan

Acute Chest Pain & TroponinCohort studyPrognosisQ3IF 1.5

Sex-specific troponin T cut-offs improved long-term mortality risk stratification after heart failure hospitalization.

The Utility of Sex-Specific Cut-offs for High-Sensitivity Troponin T for Long-Term All-cause Mortality Risk Assessment in Heart Failure.

Anamaria Draghici … Gheorghe-Andrei Dan

Romanian journal of internal medicine · Jun 2026 · Q3 in General Medicine

Background

High-sensitivity troponin T (hs-TnT) is commonly elevated in heart failure (heart failure) and may have different prognostic meaning in women and men.

Methods

We conducted a retrospective single-center cohort study derived from the HI-HF registry (2011-2014).

n = 404 patients

Results

sex-specific cutoffs classified risk more accurately than the standard threshold

70.7%

Sensitivity

78.3%

Specificity

More results

Our cohort included 404 patients.

Women had lower hs-TnT concentrations than men (median 14.18 vs 22.44 pg/mL).

ROC-derived sex-specific mortality prognostic cut-offs were >15.83 pg/mL for women (AUC 0.773; sensitivity 70.7%; specificity 78.3%) and >19.02 pg/mL for men (AUC 0.725; sensitivity 75.0%; specificity 65.0%).

More results

For each gender-defined subgroup, increased hs-TnT levels were independently associated with all-cause long-term mortality in Cox analysis alongside NT-proBNP and hemoglobin levels in men (HR 1.91 (1.07 - 3.41), p=0.029), and NT-proBNP and age in women (HR 3.54 (2.07 - 6.07), p<0.001).

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Conclusion · 1 of 2

Sex-specific hs-TnT cut-off recalibration improved long-term mortality risk stratification in hospitalized heart failure patients.

Conclusion · 2 of 2

Increased levels of hs-TnT defined by the gender-specific analysis were independent predictors of the outcome in both men and women.

The Utility of Sex-Specific Cut-offs for High-Sensitivity Troponin T for Long-Term All-cause Mortality Risk Assessment in Heart Failure.

The Utility of Sex-Specific Cut-offs for High-Sensitivity Troponin T for Long-Term All-cause Mortality Risk Assessment in Heart Failure.

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