Occupational Anaphylaxis to Piperacillin-Tazobactam in a Nurse: A Case Report.

Case reportJournal of investigative medicine high impact case reports· 2026

Occupational Anaphylaxis to Piperacillin-Tazobactam in a Nurse: A Case Report.

Guedes Catarina, Van-Beveren Patrícia, Manso-Preto Leonor … Faria E

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Allergy & ImmunologyCase reportClinical practiceQ3IF 0.7

Skin prick testing showed an exuberant wheal over 20 mm to piperacillin-tazobactam.

Occupational Anaphylaxis to Piperacillin-Tazobactam in a Nurse: A Case Report.

Guedes Catarina … Faria E

Journal of investigative medicine high impact case reports · 2026

Background

Piperacillin-tazobactam is a widely used β-lactam antibiotic, yet occupational systemic anaphylaxis remains exceptionally rare.

>20 mm

Results

>20 mm

a strongly positive, exuberant reaction, well beyond a borderline result

More results

We report the case of a 26-year-old female nurse with persistent atopic dermatitis and previous history of allergic contact dermatitis to nickel and cobalt, who developed occupational anaphylaxis while preparing intravenous cefuroxime and piperacillin-tazobactam.

More results

She later tolerated cefuroxime handling but developed a generalized rash following accidental skin contact with piperacillin-tazobactam powder.

No cofactors were identified, and no reactions occurred outside the workplace.

“

Conclusion

This case reinforces that non-therapeutic occupational exposure to piperacillin-tazobactam can lead to life-threatening IgE-mediated anaphylaxis, highlighting the need for increased awareness and structured preventive strategies in healthcare settings.

Occupational Anaphylaxis to Piperacillin-Tazobactam in a Nurse: A Case Report.

Occupational Anaphylaxis to Piperacillin-Tazobactam in a Nurse: A Case Report.

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