Age modifies the prognostic value of post-procedural high-sensitivity troponin T for mortality in patients…

Cohort studyCardiovascular revascularization medicine : including molecular interventions· Jun 2026

Age modifies the prognostic value of post-procedural high-sensitivity troponin T for mortality in patients with acute coronary syndrome: A registry study of 14,210 patients.

Kun Na, Miaohan Qiu, Zizhao Qi … Yaling Han

Acute Chest Pain & TroponinCohort studyPrognosisQ2IF 1.2

Elevated troponin T linked to higher mortality risk only in patients 65 or older

Age modifies the prognostic value of post-procedural high-sensitivity troponin T for mortality in patients with acute coronary syndrome: A registry study of 14,210 patients.

Kun Na … Yaling Han

Cardiovascular revascularization medicine · Jun 2026 · Q2 in General Medicine

Background

Post-procedural high-sensitivity cardiac troponin T (hs-TnT) is an established prognostic marker after percutaneous coronary intervention (percutaneous coronary intervention) for acute coronary syndrome (acute coronary syndrome), yet its prognostic value may not be uniform across age groups, particularly when mortality and ischemic endpoints are considered separately.

Methods

From a prospective percutaneous coronary intervention registry (March 2016-March 2019), 14,210 acute coronary syndrome patients were stratified by age (<65 vs ≥65 years) and post-procedural hs-TnT (<5× vs ≥5× upper reference limit).

n = 14,210 ACS patients

Results

risk of death rises sharply with high troponin in patients 65 or older

aHR 2.80 (95% CI 1.84 to 4.27)

null 1

1.84

4.27

CI excludes the null - significant

More results

At 12 months, 221 deaths and 312 ischemic events occurred.

A concordant pattern was observed for cardiac death (P for interaction = 0.020).

In contrast, elevated hs-TnT predicted ischemic events equally regardless of age (aged <65: aHR, 2.18; aged ≥65: aHR, 2.17; P for interaction = 0.995).

More results

Tensor product analysis confirmed a significant interaction for mortality (P = 0.048) but not for ischemic events (P = 0.935).

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Conclusion · 1 of 2

Age selectively modified the prognostic value of post-procedural hs-TnT for mortality, but not for ischemic events, in patients with acute coronary syndrome undergoing percutaneous coronary intervention.

Conclusion · 2 of 2

Age-stratified interpretation of post-procedural hs-TnT may improve post-percutaneous coronary intervention risk stratification if externally validated.

Age modifies the prognostic value of post-procedural high-sensitivity troponin T for mortality in patients with acute coronary syndrome: A registry study of 14,210 patients.

Age modifies the prognostic value of post-procedural high-sensitivity troponin T for mortality in patients with acute coronary syndrome: A registry study of 14,210 patients.

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