In vitro models of blood-spinal cord barrier in spinal cord injury: A meta-analysis of model design, performance, and physiological relevance.

This review consolidates critical insights into in vitro blood-spinal cord barrier model design and performance, providing a clear framework for developing more accurate and reliable models.

These findings will facilitate the development of effective therapeutic interventions capable of crossing the blood-spinal cord barrier, addressing a key bottleneck in mechanistic research and therapeutic development for treating spinal cord injury and other neurological diseases.