The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent…

Cohort studyCancer medicine· Aug 2026

The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent Radiotherapy With Cetuximab due to Contraindications With Cisplatin.

Esin Kiraz, Mete Gündoğ, Rıdvan Gönül … Sedat Çağlı

Head & Neck SurgeryCohort studyPrognosisQ1IF 3.6

Low G8 frailty score independently predicts worse overall survival in this population

The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent Radiotherapy With Cetuximab due to Contraindications With Cisplatin.

Esin Kiraz … Sedat Çağlı

Cancer medicine · Aug 2026

Purpose

This study evaluated the prognostic significance of the Geriatric 8 (G8) score and the Charlson Comorbidity Index (Charlson Comorbidity Index) in predicting survival outcomes in this population.

Methods

We retrospectively analyzed data from 52 patients with locally advanced or loco-regional recurrent head and neck squamous cell carcinoma (head and neck squamous cell carcinoma) who were treated with radiotherapy and cetuximab between 2011 and 2024.

n = 52 patients

HR 4.72

Results

HR 4.72

frailty score below cutoff nearly quintuples the risk of death

n = 52 patients

More results

A G8 cut-off of 9.75 was identified (AUC: 0.713, p < 0.01).

42% in low-G8 patients.

In the recurrence group, 4-year cancer-specific survival was 63% among high-G8 patients, whereas no patient with a low G8 score survived beyond 4 years.

No significant association was observed between Charlson Comorbidity Index and survival.

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Conclusion · 1 of 2

The G8 score is a valuable prognostic tool for cisplatin-ineligible head and neck squamous cell carcinoma patients treated with radiotherapy and cetuximab.

Conclusion · 2 of 2

Low G8 scores were strongly associated with worse outcomes, highlighting the need for alternative therapeutic strategies in this high-risk subgroup.

The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent Radiotherapy With Cetuximab due to Contraindications With Cisplatin.

The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent Radiotherapy With Cetuximab due to Contraindications With Cisplatin.

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