Healthcare Utilization After Biologic Initiation for Chronic Rhinosinusitis.

Cohort studyAmerican journal of rhinology & allergy· Aug 2026

Healthcare Utilization After Biologic Initiation for Chronic Rhinosinusitis.

Beau M Idler, Jananee Muralidharan, Gavin Hui, Noel F Ayoub

Read paper

Rhinology & SinusCohort studyTreatmentQ1IF 2.6

Repeat sinus surgery was more common after biologic therapy than after initial surgery

Healthcare Utilization After Biologic Initiation for Chronic Rhinosinusitis.

Beau M Idler … Noel F Ayoub

American journal of rhinology & allergy · Aug 2026 · Q1 in Otorhinolaryngology

Background

Biologic therapies for chronic rhinosinusitis with nasal polyps (chronic rhinosinusitis with nasal polyps) broaden options beyond endoscopic sinus surgery (endoscopic sinus surgery) and conventional medications.

Purpose

To compare 12-month healthcare utilization and costs after biologic initiation versus endoscopic sinus surgery.

Methods

Using the Atropos Health platform (2019-2024; ∼66 million patients), adults with chronic rhinosinusitis with nasal polyps and ≥12-month follow-up who received treatment with endoscopic sinus surgery or an approved biologic were identified.

Results

repeat surgery was more likely after biologic therapy than after initial surgery

OR by subgroup · 95% CI

More results

Of 7519 endoscopic sinus surgery and 2084 biologic-treated eligible patients, 998 remained per arm after matching.

Biologics and endoscopic sinus surgery patients had similar office (41.3% vs 38.7%; OR 0.90, 95% CI 0.77-1.07) and ED visit rates (2.0% vs 1.3%; OR 0.65, 95% CI 0.32-1.30).

More results

No significant differences were identified in Current Procedural Terminology-based costs, complication rates, or steroid use.

“

Conclusion · 1 of 2

Within 1 year, endoscopic sinus surgery and biologic patients showed similar healthcare utilization, with the exception of subsequent sinus surgery rates, which were higher in biologic patients.

Conclusion · 2 of 2

These findings may guide shared decision-making and payer policy.

Healthcare Utilization After Biologic Initiation for Chronic Rhinosinusitis.

Healthcare Utilization After Biologic Initiation for Chronic Rhinosinusitis.

Related papers