Unveiling the true impact of dominant thyroid nodules: are they really the Culprits?
Fine-needle aspiration biopsy cytology disagreed with final pathology in 20.4% of thyroid nodule cases.
Unveiling the true impact of dominant thyroid nodules: are they really the Culprits?
Multinodular goiter (multinodular goiter) is a common endocrine disorder, especially in iodine-deficient regions.
This retrospective cohort study included 266 patients with multinodular goiter, who underwent total thyroidectomy between September 2020 and December 2024 and were found to have malignancy on final pathology.
Malignancy was detected in 266 of 577 patients who underwent total thyroidectomy (46.1%), representing the malignancy rate within the surgical cohort rather than the overall multinodular goiter population.
Contralateral or bilateral malignancy was more common in patients with compression symptoms.
ROC analyses identified exploratory size cutoff values (34 mm and 30.5 mm) for predicting laterality among cases of malignancy.
Larger dominant nodules were more frequently associated with malignancy in non-dominant nodules; however, this observation should be interpreted as exploratory given the limited discriminatory performance of the ROC analyses.
These findings suggest that a thorough preoperative evaluation of all nodules, beyond the dominant one, may be warranted in selected patients with multinodular goiter.