Preoperative Prediction of Pituitary Adenoma Consistency Using Synthetic MRI and Virtual Magnetic Resonance…

Cohort studyJournal of magnetic resonance imaging : JMRI· Aug 2026

Preoperative Prediction of Pituitary Adenoma Consistency Using Synthetic MRI and Virtual Magnetic Resonance Elastography.

Yunxiao Zhou, Qichao Qi, Xinghua Xu … Jingzhen He

Skull BaseCohort studyDiagnosisQ1IF 3.1

Combining MRI stiffness, diffusion, and T2 values predicted hard vs soft pituitary adenomas

Preoperative Prediction of Pituitary Adenoma Consistency Using Synthetic MRI and Virtual Magnetic Resonance Elastography.

Yunxiao Zhou … Jingzhen He

Journal of magnetic resonance imaging · Aug 2026

Background

Pituitary macroadenomas consistency affects surgical planning and may limit complete resection.

Purpose

To evaluate the feasibility of vMRE and synthetic MRI for preoperative prediction of pituitary macroadenomas consistency.

Methods

POPULATION: Sixty-five patients with pituitary macroadenomas were prospectively enrolled (39 females; age = 49.02 ± 8.53 years).

n = 49

Results

vMRE stiffness with diffusion and T2 accurately distinguished hard from soft adenomas

0.83AUC

vMRE+ADC

0.797AUC

ADC+T2

0.86AUC

vMRE+ADC+T2

More results

Compared with soft groups, hard groups showed significantly lower T2 and apparent diffusion coefficient values and higher vMRE stiffness.

Combined models of vMRE+apparent diffusion coefficient and apparent diffusion coefficient+T2 yielded AUCs of 0.830 and 0.797, respectively.

“

Conclusion · 1 of 2

The integration of vMRE stiffness with apparent diffusion coefficient and T2 values derived from synthetic MRI demonstrated preliminary feasibility for assessing pituitary macroadenomas' consistency in this internally validated cohort, suggesting a promising multiparametric approach.

Conclusion · 2 of 2

EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 2.

Preoperative Prediction of Pituitary Adenoma Consistency Using Synthetic MRI and Virtual Magnetic Resonance Elastography.

Preoperative Prediction of Pituitary Adenoma Consistency Using Synthetic MRI and Virtual Magnetic Resonance Elastography.

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