Transition Zone Prostate Cancer: Quantitative Synthetic MR Imaging and Diffusion-Weighted Imaging in Tumour…

Cross-sectionalJournal of medical imaging and radiation oncology· Aug 2026

Transition Zone Prostate Cancer: Quantitative Synthetic MR Imaging and Diffusion-Weighted Imaging in Tumour Detection.

Yu Zhang, Feng Li, Lei Song … Shijun Jia

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Prostate CancerCross-sectionalDiagnosisQ2IF 1.3

Apparent diffusion coefficient value almost perfectly distinguishes transition zone prostate cancer from benign hyperplasia

Transition Zone Prostate Cancer: Quantitative Synthetic MR Imaging and Diffusion-Weighted Imaging in Tumour Detection.

Yu Zhang … Shijun Jia

Journal of medical imaging and radiation oncology · Aug 2026

Background

Differentiating transition zone (transition zone) prostate cancer (prostate cancer) from benign prostatic hyperplasia (benign prostatic hyperplasia) on multiparametric MRI is challenging.

Purpose

To evaluate the utility of synthetic MRI parameters and apparent diffusion coefficient in distinguishing transition zone prostate cancer from benign prostatic hyperplasia.

Methods

This retrospective study included 261 patients (89 prostate cancer, 172 benign prostatic hyperplasia) who underwent preoperative MRI (including DWI and synthetic MRI).

n = 261 patients

Results

adc alone almost perfectly tells cancer apart from benign hyperplasia

AUC 1.00 (95% CI 0.99 to 1)

null 0

0.99

1

CI excludes the null - significant

More results

T1, T2 and apparent diffusion coefficient values were significantly lower in prostate cancer than in benign prostatic hyperplasia (all p ≤ 0.001), while proton density showed no difference (p = 0.073).

“

Conclusion

Synthetic MRI-derived T1 and T2 values can help differentiate prostate cancer from benign prostatic hyperplasia in the transition zone; however, apparent diffusion coefficient remains the superior diagnostic performance within this enriched cohort of predominantly intermediate- to high-risk tumours.

Transition Zone Prostate Cancer: Quantitative Synthetic MR Imaging and Diffusion-Weighted Imaging in Tumour Detection.

Transition Zone Prostate Cancer: Quantitative Synthetic MR Imaging and Diffusion-Weighted Imaging in Tumour Detection.

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