Concomitant benign prostatic enlargement and bladder stone surgery versus bladder stone treatment alone…

Meta-analysisWorld journal of urology· Jul 2026

Concomitant benign prostatic enlargement and bladder stone surgery versus bladder stone treatment alone: results from a systematic review and meta-analysis of comparative studies by the EAU endourology section.

Angelo Cormio, Carlo Giulioni, Federico Falsetti … Daniele Castellani

Benign Prostatic DiseaseMeta-analysisTreatmentQ1IF 2.9

Combining prostate and bladder stone surgery is associated with lower stone recurrence odds

Concomitant benign prostatic enlargement and bladder stone surgery versus bladder stone treatment alone: results from a systematic review and meta-analysis of comparative studies by the EAU endourology section.

Angelo Cormio … Daniele Castellani

World journal of urology · Jul 2026 · Q1 in Urology

Background

Men with benign prostatic enlargement (benign prostatic enlargement) frequently present with concomitant bladder stones (bladder stones), yet the optimal surgical strategy remains debated.

Purpose

This systematic review and meta-analysis aimed to compare perioperative and postoperative outcomes of concomitant benign prostatic enlargement/bladder stones surgery against bladder stones treatment alone.

Methods

Following the 2020 PRISMA framework, a comprehensive search was conducted on 9 March 2026.

n = 500 patients

Results

combined surgery cut stone recurrence odds by about 80%

OR 0.18 (95% CI 0.10 to 0.33)

null 1

0.10

0.33

CI excludes the null - significant

More results

Quality assessment revealed some concerns in the overall risk of bias for the single randomized trial, while non-randomized studies showed moderate (3 studies) and high overall risk of bias (3 studies).

More results

Minor complications (Clavien 1-2) were more frequent in the concomitant surgery group (OR 4.35, p < 0.0001), while major complications and stone-free rates did not differ significantly, though the comparison was likely underpowered for major complications.

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Conclusion

Concomitant benign prostatic enlargement and bladder stones surgery substantially reduces stone recurrence and improves lower urinary tract symptoms without meaningfully increasing serious perioperative risk, supporting its adoption in selected cases when bladder stones is related to benign prostatic enlargement with bladder outlet obstruction.

Concomitant benign prostatic enlargement and bladder stone surgery versus bladder stone treatment alone: results from a systematic review and meta-analysis of comparative studies by the EAU endourology section.

Concomitant benign prostatic enlargement and bladder stone surgery versus bladder stone treatment alone: results from a systematic review and meta-analysis of comparative studies by the EAU endourology section.

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