Benign but burdensome: Complications and management of benign prostatic hyperplasia during active surveillance of prostate cancer in a large cohort.
13% of men on prostate cancer active surveillance developed a benign prostatic hyperplasia complication.
Benign but burdensome: Complications and management of benign prostatic hyperplasia during active surveillance of prostate cancer in a large cohort.
To evaluate the prevalence of benign prostatic hyperplasia (benign prostatic hyperplasia) interventions, incidence of benign prostatic hyperplasia-related complications, and subsequent management among men on active surveillance (active surveillance) for prostate cancer (CaP).
We retrospectively analyzed a prospectively maintained active surveillance database from a single tertiary cancer center.
larger prostates raise the odds of a benign prostatic hyperplasia complication on surveillance
Prior to active surveillance, 24% had received lower urinary tract symptoms-directed treatment.
During active surveillance, 278 men (38%) underwent lower urinary tract symptoms intervention with medications or surgery.
Larger prostate volume was independently associated with increased odds of complications (OR 1.03 per cc, 95% CI 1.02-1.04, P < 0.001).
Among men with complications, 17 (17.7%) underwent benign prostatic hyperplasia surgery.
Benign prostatic hyperplasia-related complications are common among men on active surveillance, yet definitive surgical management is infrequently pursued even after complications.
Larger prostate volume identifies patients at increased risk.
These findings highlight the need for systematic assessment and evidence-based management of lower urinary tract symptoms/benign prostatic hyperplasia in the active surveillance population.