Multilayer network analysis of dynamic network reconfiguration in alcohol use disorder and its association with multidomain cognitive impairments and neurotransmitter system.

Multilayer network analysis revealed instability of brain dynamics in alcohol use disorder patients, correlating with alcohol use disorder severity, cognitive impairment and multiple neurotransmitter system.

These findings provide preliminary evidence of spatial associations between alcohol use disorder-related network dynamic abnormalities and neurotransmitter receptor distributions, as well as nominal exploratory correlations with clinical severity and cognitive performance.