Sighing Dynamics as a Candidate Digital Biomarker for Anxiety in Daily Life Using Wearable Respiratory Monitoring: Intensive Longitudinal Study.

The analysis included 1279 synchronized psychophysiological windows from 33 participants.

Five participants were excluded due to insufficient valid synchronized windows.

The within-person anxiety-by-group interaction was significant (OR 1.14, 95% CI 1.03-1.26; P=.01), indicating that sighing tended to increase with higher momentary anxiety in healthy controls but was attenuated in participants with anxiety disorders.