Comparing 8-Year Survival Rates in Older-Age Bipolar Disorder (OABD) and Its Clinical Predictors to the…

Cohort studyThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry· Jul 2026

Comparing 8-Year Survival Rates in Older-Age Bipolar Disorder (OABD) and Its Clinical Predictors to the General Population.

Nazila Bayat, Adriaan W Hoogendoorn, Karolin Schwellnus … Annemiek Dols

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Mood DisordersCohort studyPrognosisQ1IF 2.6

Older adults with bipolar disorder face higher 8-year mortality than matched peers

Comparing 8-Year Survival Rates in Older-Age Bipolar Disorder (OABD) and Its Clinical Predictors to the General Population.

Nazila Bayat … Annemiek Dols

The American journal of geriatric psychiatry · Jul 2026 · Q1 in Psychiatry

Purpose

W?>Bipolar disorder (bipolar disorder) is associated with reduced life expectancy, but it is unknown if this extends into later life or if older-age bipolar disorder (older-age bipolar disorder) represents a survival cohort.

Methods

In this prospective cohort study, 227 adults aged ≥50 years with bipolar disorder from the Dutch Older Bipolars (Dutch Older Bipolars) study were compared with 681 matched (on age and sex) controls (CG) from the Longitudinal Aging Study Amsterdam (Longitudinal Aging Study Amsterdam).

n = 227 adults

Results

bipolar adults had roughly 1.7 times the risk of dying versus peers

HR 1.72 (95% CI 1.17 to 2.54)

CI excludes the null - significant

More results

In total, 37 (16.3%) older-age bipolar disorder and 138 (20.3%) CG participants died during the 8-year follow-up.

Kaplan-Meier curves indicated earlier mortality in older-age bipolar disorder.

More results

Restricted mean survival time over 7.5 years was 2500.7 days (95% confidence interval [CI] 2419.9-2581.5) in older-age bipolar disorder and 2607.2 days (95% CI 2572.3-2642.0) in CG, corresponding to an average survival difference of 106.4 days (3.5 months; 95% CI 18.4-194.5; p = 0.018).

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Conclusion · 1 of 3

In this longitudinal cohort study, older-age bipolar disorder had significantly higher all-cause mortality than age- and sex-matched population controls, with a shorter restricted mean survival time and an increased hazard of death over 8 years.

Conclusion · 2 of 3

Thus, excess mortality persists into later life, and older-age bipolar disorder is not solely a survivor cohort.

Conclusion · 3 of 3

Targeted strategies addressing modifiable physical health and lifestyle risk factors are warranted to reduce premature mortality in this vulnerable population.

Comparing 8-Year Survival Rates in Older-Age Bipolar Disorder (OABD) and Its Clinical Predictors to the General Population.

Comparing 8-Year Survival Rates in Older-Age Bipolar Disorder (OABD) and Its Clinical Predictors to the General Population.

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