Efficacy of Tranexamic acid Microneedling versus Intradermal Injection of Tranexamic Acid in the Treatment of Melasma - A Randomised Controlled Trial.

Both groups showed significant reduction in mMASI scores from baseline to 20 weeks (7.1 ± 2.3 to 4.6 ± 0.5 in Group A and 7.0 ± 3.1 to 5.3 ± 0.7 in Group B, respectively).

From 12 th week onwards, Group A had significantly lower mMASI scores than Group B ( P < 0.05).

Photographic documentation revealed that over 75.0% of Group A patients had more than 50.0% improvement, against 40.0% in Group B ( P < 0.05).

Adverse events such as erythema, pain, burning sensation, and pigmentation were slightly more common in Group B, but the difference was not statistically significant.