A smarter dermal filler: Antimicrobial protection and collagen stimulation with niacinamide.

Animal / preclinicalEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V· Jul 2026

A smarter dermal filler: Antimicrobial protection and collagen stimulation with niacinamide.

Alexandre Porcello, Cindy Schelker, Olivier Jordan … Viorica Patrulea

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Cosmetic & AestheticAnimal / preclinicalQ2IF 5.3

Niacinamide-enriched filler inhibited about 90% of Gram-negative bacterial growth in lab tests.

A smarter dermal filler: Antimicrobial protection and collagen stimulation with niacinamide.

Alexandre Porcello … Viorica Patrulea

European journal of pharmaceutics and biopharmaceutics · Jul 2026 · Q2 in General Medicine

Background

Biological skin aging involves structural changes, including flattening of the epidermal-dermal junction and reduced collagen types I and III.

Methods

We evaluated the biostimulatory, antimicrobial, anti-inflammatory, and safety profiles of a new niacinamide-enriched cross-linked hyaluronic acid dermal filler (HAR) compared to untreated controls and Belotero Balance® (commercial reference).

Results

cuts growth of common gram-negative bacteria almost entirely

90%

Gram-negative

50%

Gram-positive

More results

Niacinamide is a well-established molecule that stimulates collagen synthesis, modulates inflammation and inhibits bacterial growth.

HAR-treated explants displayed improved epidermal architecture, and a denser collagen type I network.

“

Conclusion

These findings highlight HAR as a multifunctional dermal filler combining essential structural support with regenerative, antibacterial, and anti-inflammatory benefits.

A smarter dermal filler: Antimicrobial protection and collagen stimulation with niacinamide.

A smarter dermal filler: Antimicrobial protection and collagen stimulation with niacinamide.

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