Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study.

Cohort studyDermatopathology (Basel, Switzerland)· Mar 2026

Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study.

Maroun Bou Zerdan, Kevin T Jamouss, Alexandre Maalouf … Jeffrey Ross

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Skin Cancer & MelanomaCohort studyDiagnosisQ2IF 2.0

Sebaceous carcinomas show more genomic alterations per tumor than sweat gland carcinomas.

Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study.

Maroun Bou Zerdan … Jeffrey Ross

Dermatopathology (Basel, Switzerland) · Mar 2026 · Q2 in Dermatology

Results

sebaceous tumors carry more genomic alterations than sweat gland tumors

38.2%

SEB RB1 alterations

8.1%

SWT RB1 alterations

More results

A total of 276 carcinomas cases underwent hybrid capture-based comprehensive genomic profiling (comprehensive genomic profiling) to assess all classes of genomic alterations (genomic alterations).

More results

Histologically, 173 tumors (62.7%) were sweat gland-derived (SWT), 55 (19.9%) sebaceous gland-derived (SEB), 14 (5.1%) hair follicle-derived (HRF), and 34 (12.3%) unclassified (UNK).

Among SWT tumors, 150 (86.7%) were eccrine and 23 (13.3%) apocrine.

“

Conclusion

Prospective clinical trials are needed to determine the prognostic and predictive value of carcinomas-specific biomarkers for immune checkpoint inhibitor (immune checkpoint inhibitor) response, which is essential for integrating novel therapies into the evolving treatment landscape.

Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study.

Comprehensive Genomic Profiling of Cutaneous Adnexal Carcinomas: A Genomic Landscape Study.

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