A Nomogram for the Diagnosis of Plaque Psoriasis Using Histopathological Characteristics.

Cohort studyThe American Journal of dermatopathology· Jul 2026

A Nomogram for the Diagnosis of Plaque Psoriasis Using Histopathological Characteristics.

Hai-Yang He, Sheng Fang

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Inflammatory & ImmunodermatologyCohort studyDiagnosisQ3IF 0.6

New histopathology nomogram distinguishes plaque psoriasis from mimics with near-perfect accuracy.

A Nomogram for the Diagnosis of Plaque Psoriasis Using Histopathological Characteristics.

Hai-Yang He, Sheng Fang

The American Journal of dermatopathology · Jul 2026 · Q3 in Dermatology

Background

Diagnostic uncertainty of plaque psoriasis (plaque psoriasis) persists when dermatopathologists encounter clinicopathologically ambiguous cases.

Purpose

We aim to develop a nomogram based on histopathological features to improve the accuracy of the diagnosis of plaque psoriasis.

Methods

A total of 192 samples from 186 patients with plaque psoriasis and 170 samples from 166 control patients were used in the derivation cohort.

n = 192 samples

Results

correctly separated plaque psoriasis from mimics nearly every time, 1.0 is perfect

AUC 0.98 (95% CI 0.97 to 0.99)

CI excludes the null - significant

More results

Nine variables were selected for a diagnostic nomogram of plaque psoriasis.

The calibration plot showed strong agreement between the prediction of the nomogram and the actual diagnosed plaque psoriasis.

The decision curve analysis revealed that the nomogram had good clinical utility.

“

Conclusion

The sensitivity and specificity of histopathological features were investigated and a well-performing nomogram was developed to aid diagnosing plaque psoriasis. However, broader application awaits further fine tuning of the model.

A Nomogram for the Diagnosis of Plaque Psoriasis Using Histopathological Characteristics.

A Nomogram for the Diagnosis of Plaque Psoriasis Using Histopathological Characteristics.

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