Persistence and Contemporary Clinical Applications of Mohs Paste: A Scoping Review.

ReviewThe Journal of dermatology· Aug 2026

Persistence and Contemporary Clinical Applications of Mohs Paste: A Scoping Review.

Airin Sato, Yu Matsui, Shohei Kitayama, Tadamichi Shimizu

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Dermatologic SurgeryReviewClinical practiceQ1IF 1.8

Bleeding control was reported in most patients treated with Mohs paste.

Persistence and Contemporary Clinical Applications of Mohs Paste: A Scoping Review.

Airin Sato … Tadamichi Shimizu

The Journal of dermatology · Aug 2026 · Q1 in Dermatology

Background

Mohs paste (mohs paste), a zinc chloride-based tissue fixative developed by Frederic E.

Methods

Were mostly female (80.7%) with a median age of 68 years, and most presented with locally advanced or stage III-IV disease.

n = 88 patients

Results

most patients had their bleeding controlled with mohs paste

78.4%

Bleeding control

62.5%

Reduction of exudate

47.7%

Reduction of malodor

44.3%

Reduction of tumor vol

More results

Japan remains a notable exception; mohs micrographic surgery is not as widely adopted there, while mohs paste persists as a symptom-directed practice across multiple disciplines.

We systematically characterized the indications, applications, and limitations of mohs paste to contextualize its contemporary clinical relevance.

More results

Fifty-two studies (1964-2024) described 88 patients (36 case reports; 16 case series), predominantly from Japan (48 reports).

At least one local outcome was reported in 87 patients (98.9%), based on descriptive and non-standardized reporting.

“

Conclusion

These findings highlight the need for standardized protocols, registry-based evaluation, and clearer positioning of mohs paste within contemporary clinical practice.

Persistence and Contemporary Clinical Applications of Mohs Paste: A Scoping Review.

Persistence and Contemporary Clinical Applications of Mohs Paste: A Scoping Review.

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