Mechanistic study on the treatment of androgenetic alopecia with Platycladus orientalis leaf extract via regulation of the VEGFA/Bcl2 pathway: An in silico and in vitro study.

Active compounds and their potential targets in POE were first identified.

POE promotes dermal papilla cell proliferation and angiogenesis by activating vascular endothelial growth factor A/Bcl-2 signaling.

Network pharmacology screened 28 compounds against 506 androgenetic alopecia targets; the top 6 (amentoflavone, isoquercitrin, afzelin, phloretin, pinusolide, and quinic acid) were docked to vascular endothelial growth factor A (threshold Vina score < -7.0).