Evaluation of the interrelationship between inflammatory markers, rosacea, ocular symptoms, and migraine…

StudyCutaneous and ocular toxicology· Jul 2026

Evaluation of the interrelationship between inflammatory markers, rosacea, ocular symptoms, and migraine comorbidity.

Fatma Etgü, Ahmet Burak Gürpınar, Didem Erol, Asena Keleş Şahin

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Acne & RosaceaStudyDiagnosisQ3IF 1.6

Ocular symptoms occur in over half of rosacea patients, more common with migraine.

Evaluation of the interrelationship between inflammatory markers, rosacea, ocular symptoms, and migraine comorbidity.

Fatma Etgü … Asena Keleş Şahin

Cutaneous and ocular toxicology · Jul 2026 · Q3 in General Medicine

Background

Rosacea is a chronic dermatological condition frequently associated with ocular symptoms and neurological comorbidities such as migraine.

Purpose

This study aimed to compare inflammatory and hematological markers between rosacea patients and healthy controls, and to assess differences in these markers among rosacea patients based on the presence or absence of ocular symptoms and migraine.

Methods

A total of 150 rosacea patients and age- and gender-matched healthy controls were enrolled.

n = 150 rosacea patients and age- and

51.3%

Results

51.3%

just over half of rosacea patients have ocular symptoms, more so with migraine

n = 150 rosacea patients and age- and

More results

Compared with healthy controls, rosacea patients had higher white blood cell counts (7.22 ± 1.60 vs 6.83 ± 1.38, p = 0.03) and neutrophil counts ( p = 0.02), and lower eosinophil counts ( p = 0.036), mean corpuscular volume ( p < 0.001), and red cell distribution width-standard deviation ( p = 0.015).

More results

Mean corpuscular hemoglobin concentration was higher in rosacea patients ( p = 0.001).

Headaches and migraine were more prevalent in rosacea patients than in controls ( p < 0.0001 and p = 0.0006, respectively).

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Conclusion

Rosacea was associated with changes in hematological and inflammatory markers, as well as a higher prevalence of migraine and ocular symptoms. These findings support the need for comprehensive evaluation of patients with rosacea.

Evaluation of the interrelationship between inflammatory markers, rosacea, ocular symptoms, and migraine comorbidity.

Evaluation of the interrelationship between inflammatory markers, rosacea, ocular symptoms, and migraine comorbidity.

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