Leciplex Nanocarriers: An Optimized Platform for Thymol Delivery in Acne Management.
Thymol-Leciplex gel cut ear skin swelling more than thymol gel alone in rats
Leciplex Nanocarriers: An Optimized Platform for Thymol Delivery in Acne Management.
Antibiotics are commonly used for acne treatment.
This study investigated the effectiveness of Leciplex cationic nanovesicles encapsulating thymol (LPX-THY) as a promising topical acne management strategy.
Leciplex nanovesicles were assembled using soy phosphatidylcholine (soy phosphatidylcholine) and cationic surfactants and characterized in terms of particle size, zeta potential, entrapment efficiency, morphology, in vitro release, and ex vivo skin permeation.
swelling dropped most with thymol-Leciplex gel, outperforming plain thymol or blank gel
Optimal THY-LPX nanovesicles made of soy phosphatidylcholine and Dimethyldidodecylammonium bromide DDAB in a 1:1 molar ratio showed circular outline with particle size, zeta potential, and entrapment efficiency of 187.7 ± 1.78 nm, 36.97 ±0.21 mV, and 60.5 ± 2.3%, respectively.
THY-LPX gel demonstrated minimum inhibitory concentration (minimum inhibitory concentration) and minimum bactericidal concentration (minimum bactericidal concentration) at a concentration of 156.25 µg·mL -1 against Staphylococcus aureus, a clear absence of biofilm coating under SEM, and substantial red fluorescence, indicating reduction in viable bacteria under a confocal laser microscope.
The developed thymol-LPX gel serves as a potential topical delivery platform of thymol for acne therapy.