Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne: Pooled Analysis by Age and Sex.

Randomized trialJournal of drugs in dermatology : JDD· Aug 2026

Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne: Pooled Analysis by Age and Sex.

Julie C Harper, Heather C Woolery-Lloyd, Linda Stein Gold … Leon H Kircik

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Acne & RosaceaRandomized trialTreatmentQ2IF 1.7

Triple-combination acne gel cut lesions by at least 70% across age and sex

Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne: Pooled Analysis by Age and Sex.

Julie C Harper … Leon H Kircik

Journal of drugs in dermatology · Aug 2026 · Q2 in Dermatology

Background

Acne pathophysiology and presentation may differ by patient age or sex.

Purpose

This post hoc analysis evaluated CAB efficacy/safety by age and sex.

Methods

In one phase 2 and two phase 3 double-blind, randomized, 12-week trials, participants aged ≥9 years with moderate to severe acne applied once-daily CAB or vehicle.

n = 274

≥70%

Results

≥70%

gel cut acne lesions by most, regardless of age or sex

n = 274

More results

For all efficacy endpoints, CAB was superior to vehicle for younger participants and older females (P≤0.05, all).

CAB treatment-emergent adverse events rates were consistent with the overall population.

“

Conclusion

In 3 clinical trials, CAB, the only fixed-dose, triple-combination topical for acne, demonstrated ≥70% lesion reductions, with good tolerability regardless of participants' sex or age. &nbsp.

Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne: Pooled Analysis by Age and Sex.

Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Acne: Pooled Analysis by Age and Sex.

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