Dermoscopic-Pathologic Correlates of Invasiveness and Nevus Visibility in Nevus-Associated Melanoma.

ObservationalExperimental dermatology· Aug 2026

Dermoscopic-Pathologic Correlates of Invasiveness and Nevus Visibility in Nevus-Associated Melanoma.

Marco Spadafora, Erica Baschieri, Simonetta Piana … Caterina Longo

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Skin Cancer & MelanomaObservationalDiagnosisQ1IF 3.3

Invasive nevus-associated melanoma more often shows a dermoscopically visible nevus component

Dermoscopic-Pathologic Correlates of Invasiveness and Nevus Visibility in Nevus-Associated Melanoma.

Marco Spadafora … Caterina Longo

Experimental dermatology · Aug 2026 · Q1 in Dermatology

Background

Nevus-associated melanoma (nevus-associated melanoma) is histologically defined by coexisting nevus and melanoma components, yet the nevus component is frequently not visible on dermoscopy.

Methods

We performed a retrospective, single-centre observational study including histologically diagnosed NAMs (2011-2024).

Results

Odds of a visible nevus under dermoscopy were 2.5-fold higher with invasive vs in situ melanoma

OR by subgroup · 95% CI

More results

Histopathology was systematically revised to quantify nevus proportion, size, and depth.

Univariate and multivariable logistic regression evaluated associations with (a) invasive vs. in situ nevus-associated melanoma and (b) dermoscopically visible vs. non-visible nevus component.

More results

Among 340 NAMs, 36.8% were in situ and 63.2% invasive.

A dermoscopic nevus was visible in 45.6%.

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Conclusion

Dermoscopic markers of invasiveness should prompt timely management even when an associated nevus is suspected.

Dermoscopic-Pathologic Correlates of Invasiveness and Nevus Visibility in Nevus-Associated Melanoma.

Dermoscopic-Pathologic Correlates of Invasiveness and Nevus Visibility in Nevus-Associated Melanoma.

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