Association between Corticosteroids and In-Hospital Mortality After Cardiac Arrest: A Multicenter Study Using the eICU Collaborative Research Database.

Significant effect heterogeneity emerged across phenotypes.

Survival benefits were exclusively observed in comatose patients (Glasgow Coma Scale ≤8) and those with comorbid chronic obstructive pulmonary disease, whereas non-comatose patients derived no benefit.

Notably, while corticosteroids were associated with higher rates of favorable functional neurological recovery, mortality benefits did not significantly differ across systemic inflammatory marker strata.