Genetic and sociodemographic factors associated with trajectories of physical and mental health multimorbidity in a South Asian cohort in the UK: A multistate modelling analysis.

We used multi-state models to investigate trajectories in ICM-MMPRS and risk of major cardiovascular or renal events (CVR) or non-CVR death.

We used flexible parametric models to estimate baseline hazards for health state transitions, adjusting for sociodemographic factors, a polygenic risk score (polygenic risk score) for ICM-MMPRS (ICM-MMPRS), and describe 10-year simulated health state probabilities.

Younger age was associated with higher risk of developing internalising conditions.