The Geriatric Nutritional Risk Index and its association with all-cause mortality in cancer patients with sepsis: a dual-center retrospective cohort study.
Lower Geriatric Nutritional Risk Index linked to higher mortality in cancer patients with sepsis
The Geriatric Nutritional Risk Index and its association with all-cause mortality in cancer patients with sepsis: a dual-center retrospective cohort study.
The Geriatric Nutritional Risk Index (Geriatric Nutritional Risk Index) is a validated nutritional assessment tool predictive of outcomes in elderly patients, yet its prognostic value in adult cancer patients with sepsis remains unexplored.
This retrospective cohort study included adult cancer patients with sepsis from two sources: 523 patients from Guangxi Medical University Cancer Hospital ICU (2013-2024) and 4,447 patients from the MIMIC-IV database (2008-2019).
excellent accuracy at predicting death, 1.0 would be perfect
In Cox multivariable regression analysis, Geriatric Nutritional Risk Index levels were independently associated with reduced mortality in both cohorts.
Restricted cubic spline (restricted cubic splines) curves demonstrated a linear dose-response relationship between Geriatric Nutritional Risk Index and mortality.
Decision curve analysis confirmed favorable net clinical benefit across a wide range of risk thresholds.
Integrated discrimination improvement and net reclassification improvement verified that Geriatric Nutritional Risk Index significantly improved risk classification.
Among adult patients with cancer and sepsis, a lower Geriatric Nutritional Risk Index is associated with increased short- and medium-term all-cause mortality.
Geriatric Nutritional Risk Index showed excellent discriminative ability, good calibration, favorable clinical net benefit, significant improvement in risk classification, and robust stability in internal validation, with consistent performance in external validation.
Geriatric Nutritional Risk Index may serve as a simple, reliable prognostic tool for risk stratification and early nutritional intervention in this high-risk population.